THE NATURE OF THE RESPONSES OF SMOOTH MUSCLE TO ADRENIN AND THE AUGMENTOR ACTION OF COCAINE FOR SYMPATHETIC STIMULI

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Abstract
The summation of responses to adrenin and simultaneous sympathetic nervous impulses, and the effects of cocaine on the contractions evoked by nervous stimulation were studied in the nictitating membrane of the cat. Summation of the responses of the muscle to simultaneous action of both types of stimuli occurs freely. The muscle under the influence of adrenin is not refractory to nervous impulses. It is concluded that the responses to adrenin are contractions and not contrac-tures. The contractions obtained by nervous stimulation are greater after administration of cocaine. This fact is correlated with the chemical mediation of autonomic nervous impulses.

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