Diminution De La Consommation Maximum D'Oxygène Après Blocage Des Récepteurs β-Adrénergiques

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Abstract
VO2 max, maximum oxygen uptake, has been measured in 4 normal young men, before and after β-adrenergic blockade (0.5 to 5 mg Pindolol by mouth). Pindolol induces bradycardia and reduces V̇O2 max. A statistically significant positive correlation appears between poso-logy of Pindolol and bradycardia, this posology and reduction of V̇O2 max, and finally between bradycardia and reduction of V̇O2 max. These correlations indicate that the reduction of V̇O2 max is best explained by a circulatory limitation of oxygen supply to active muscles.