Expression of liver‐intestine cadherin and its possible interaction with galectin‐3 in ductal adenocarcinoma of the pancreas

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Abstract
Liver‐intestine (LI) cadherin represents a novel type of cadherin within the cadherin superfamily, and is distinguished from other cadherins by specific structural and functional features. Among normal tissues, LI‐cadherin is known to be expressed in the intestinal mucosa, while its expression in cancerous tissue has not been investigated to date, except in gastric carcinoma. In the present study we investigated LI‐cadherin expression immunohis‐tochemically using our newly established monoclonal antibody in a large set (n=102) of tumor specimens from patients with ductal adenocarcinoma of the pancreas, and correlated the findings with the patients' survival. LI‐cadherin expression was seen focally in normal pancreatic ducts. In carcinoma, well‐differentiated carcinoma cases strongly expressed LI‐cadherin, whereas less differentiated areas and poorly differentiated carcinoma cases expressed less or were negative. Kaplan‐Meier analysis for all patients demonstrated that high Ll‐cadherin expression (>25% of cells stained positive) correlated with good survival (P