Chloride anion transport and copper-mediated DNA cleavage by C-ring functionalized prodigiosenes
- 17 April 2007
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 26,p. 2701-2703
- https://doi.org/10.1039/b701919j
Abstract
A new class of prodigiosenes with stability-enhancing functionalities appended to the C-ring were found to transport chloride anions through liposomal membranes, as well as to induce copper-mediated DNA cleavage.Keywords
This publication has 32 references indexed in Scilit:
- Regulating Supramolecular Function in Membranes: Calixarenes that Enable or Inhibit Transmembrane Cl− TransportAngewandte Chemie International Edition in English, 2006
- Proteomic analysis of prodigiosin-induced apoptosis in a breast cancer mitoxantrone-resistant (MCF-7 MR) cell lineInvestigational New Drugs, 2006
- Synthesis and Anion Binding Properties of N,N‘-Bispyrrol-2-yl-2,5-diamidopyrroleOrganic Letters, 2006
- Indoloprodigiosins from the C-10 bipyrrolic precursor: New antiproliferative prodigiosin analogsBioorganic & Medicinal Chemistry Letters, 2006
- Non-apoptotic concentrations of prodigiosin (H+/Cl− symporter) inhibit the acidification of lysosomes and induce cell cycle blockage in colon cancer cellsLife Sciences, 2005
- Cycloprodigiosin hydrochloride, a H + /Cl − symporter, induces apoptosis in human breast cancer cell linesZeitschrift für Krebsforschung und Klinische Onkologie, 2000
- Cycloprodigiosin hydrochloride, a new H+/Cl− symporter, induces apoptosis in human and rat hepatocellular cancer cell lines in vitro and inhibits the growth of hepatocellular carcinoma xenografts in nude miceHepatology, 1999
- Short synthesis of undecylprodigiosine. A new route to 2,2’-bipyrrolyl-pyrromethene systemsSynlett, 1996
- Prodigiosin 25‐C uncouples vacuolar type H+‐ATPase, inhibits vacuolar acidification and affects glycoprotein processingFEBS Letters, 1995
- Über das Prodigiosin, den roten Farbstoff des Bacillus Prodigiosus (I. Mitteil.)Berichte der deutschen chemischen Gesellschaft (A and B Series), 1929