Easy Ambient Sonic-Spray Ionization-Membrane Interface Mass Spectrometry for Direct Analysis of Solution Constituents
- 8 January 2008
- journal article
- research article
- Published by American Chemical Society (ACS) in Analytical Chemistry
- Vol. 80 (3) , 898-903
- https://doi.org/10.1021/ac701960q
Abstract
Using a cellulose dialysis membrane and aqueous solutions of common drugs as a proof-of-principle example, we demonstrate that solid but permeable and flexible membranes can be used as interfaces for the direct analysis of solution constituents via easy ambient sonic-spray ionization mass spectrometry. This new combination of MS techniques, herein termed EASI-MIMS, promotes droplet pick up of the analyte from the external surface of the membrane from where the analyte has selectively permeated for proper mass spectrometry characterization and quantitation. Possible application of EASI-MIMS such as the environmental analyses of effluents, on-line monitoring of fermentation and biotransformations and on-line pharmacokinetic blood analysis are discussed.Keywords
This publication has 17 references indexed in Scilit:
- Desorption sonic spray ionization for (high) voltage‐free ambient mass spectrometryRapid Communications in Mass Spectrometry, 2006
- Characterization of a mini membrane inlet mass spectrometer for on‐site detection of contaminants in both aqueous and liquid organic samplesRapid Communications in Mass Spectrometry, 2006
- Real-time monitoring of a pharmaceutical process reaction using a membrane interface combined with atmospheric pressure chemical ionisation mass spectrometryAnalytica Chimica Acta, 2005
- Monitoringd-Serine Dynamics in the Rat Brain Using Online Microdialysis-Capillary ElectrophoresisAnalytical Chemistry, 2004
- On-Line Coupling of Microdialysis Sampling with Microchip-Based Capillary ElectrophoresisAnalytical Chemistry, 2004
- Trace level analysis of VOCs and semi-VOCs in aqueous solution using a direct insertion membrane probe and trap and release membrane introduction mass spectrometryThe Analyst, 2000
- Quantitative Determination of Semivolatile Organic Compounds in Solution Using Trap-and-Release Membrane Inlet Mass SpectrometryAnalytical Chemistry, 1997
- A Cryotrap Membrane Introduction Mass Spectrometry System for Analysis of Volatile Organic Compounds in Water at the Low Parts-per-Trillion LevelAnalytical Chemistry, 1996
- A fully integrated trap‐membrane inlet mass spectrometry system for the measurement of semivolatile organic compounds in aqueous solutionRapid Communications in Mass Spectrometry, 1995
- Direct detection and identification of volatile organic compounds dissolved in organic solvents by reversed-phase membrane introduction tandem mass spectrometryAnalytical Chemistry, 1992