Effect of a topical erythromycin-zinc formulation on sebum delivery. Evaluation by combined photometric-multi-step samplings with SebutapeR

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Abstract
Zinc displays‘in vitro’some antiandrogen activity through an inhibition of the 5α-reductase activity. The clinical relevance of this effect is unknown, particularly during zinc therapy of acne. As sebum production could he a pharmacological target, a sensitive method was used for measuring the rate of sebum delivery to the skin surface during treatment with a topical 4% crythromy-cin-1·2% zinc acetate formulation. A series of four successive 1-h samplings with Sebutape® was taken to derive the rate of sebum output from the slope of the regression line given by cumulative data. As a control the classical photometric method was used. Such combined evaluation revealed a sebosuppressive effect for the topical zinc formulation tested.

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