The control of glucose 1,6-bisphosphatase by Ca2+ and calmodulin
- 15 November 1982
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 208 (2) , 517-519
- https://doi.org/10.1042/bj2080517
Abstract
1. The control of glucose 1,6-bisphosphatase activity, the enzyme that degrades glucose 1,6-bisphosphate, a metabolite that regulates hexose phosphate metabolism, has been examined in a rat muscle extract. 2. The enzyme has been found to be activated by physiological Ca2+ concentrations. Ca2+ can be replaced by Sr2+ and Mn2+, but the effects are not so pronounced. 3. The Ca2+ effect is inhibited by EGTA. Trifluoperazine also inhibits enzyme activity. This effect can be reversed by adding exogenous calmodulin.Keywords
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