A γl Heavy‐Chain Disease Protein (EST) Lacking the Entire VH and CH1 Domains

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Abstract
Aγl heavy-chain disease protein (EST) is described which lacks the entire VH and CH1 domains and starts with the normal sequence of γ1 H-chains corresponding to the beginning of the hinge region (position 216). Although degradation cannot be excluded with certainty, it is probable that this protein is synthesized as an internally deleted γ heavy-chain disease protein. Presumably a DNA recombination has occurred resulting in the deletion of the genes coding for the VH and CH1 domains with splicing of the precursor RNA to the sequence coding for the hinge region.
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