Dominant T‐Cell Receptor β‐Chain Gene Rearrangements Indicate Clonal Expansion in the Rheumatoid Joint
- 1 January 1990
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 31 (1) , 121-125
- https://doi.org/10.1111/j.1365-3083.1990.tb02750.x
Abstract
Miltenburg, A.M.M., van Laar, J.M., Daha, M.R., de Vries, R.R.P., van den Elsen, P.J. & Breedveld, F.C. Dominant T-Cell Receptor β-Chain Gene Rearrangements Indicate Clonal Expansion in the Rheumatoid Joint. Scand. J. Immunol. 31, 121-125, 1990 T-cell receptor (TcR) β and δ gene rearrangements were studied in anti-CD3 expanded T-cell populations cultured from the synovial membrane (SM) (n=5) or synovial fluid (SF) (n=2) of rheumatoid arthritis (RA) patients. Dominant TcR β-chain gene rearrangements to Cβ1 were demonstrated in all the patients tested and 1-3 expanded clones per patient were found. Clonal rearrangements to Cβ2 were detected in one SM sample (two clones) and one SF sample (one clone). The TcR δ gene was deleted in all the samples tested. We conclude that clonal dominance may be present, either using the Cβ1 or Cβ2 gene segment.Keywords
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