Crystalluria Potential of Cholecystographic Agents

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Abstract
A FATAL case of acute renal insufficiency that followed administration of a cholecystographic agent, bunamiodyl sodium, to a forty-four-year-old woman was recently reported in this journal.1 Since the nature of the nephrotoxicity of this and similar agents is not known and, further, since it was reported that at autopsy in this case, the kidney tubules contained "crystals" it was thought of interest to consider what potential exists for occurrence of crystalluria from the use of cholecystographic agents. Some recent work has shown that it is possible to evaluate the crystalluria potential of sulfonamides as well as to estimate minimum rates . . .