Vaccination of Infants with Living Attenuated Measles Vaccine (Edmonston Strain) with and without Gamma-globulin

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Abstract
The vaccination reaction and antibody response to Edmonston B and 3 further attenuated measles vaccines derived from Ender''s strains have been examined in a total of 122 English infants. Ender''s original vaccine alone or with further attenuation by 20 or 24 extra passages in chick-embryo tissue produced reactions which were modified by gamma-globulin in as small a dosage as 0.004 ml/lb. (0.0088 ml/kg) body weight. Vaccine 20, a further-attenuated vaccine given without gamma-globulin, caused only mild reactions but a satisfactory antibody response. Of the vaccines so far tested it appears to hold most promise of proving acceptable for routine use.