ANTI-TUMOUR IMMUNITY BY NORMAL ALLOGENEIC BLOOD-TRANSFUSION IN RAT

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 27  (3) , 549-554
Abstract
Growth of transplantable KMT-17 [fibrosarcoma] tumor cells in syngeneic WKA/Mk rats was inhibited by i.v. preimmunization with whole blood from normal rats of allogeneic strains. The inhibitory effect was also observed in rats immunized with allogeneic white blood cells alone. The strength of the inhibitory effect mainly depended on the strain of donor rat used; blood from Donryu and Kyoto strain rats produced the strongest inhibition, blood from Tokyo and Fischer strain rats produced moderate inhibition to the syngeneic tumor growth. Blood from ACI/N strain rats did not produce the inhibition. The mechanism of blood transfusion in inhibiting tumor growth is not clear. GVH [graft vs. host] reaction probably does not play an important role in the mechanism of the inhibition effect, because the effect was obtained by immunization with mitomycin C-treated allogeneic white blood cells and also by the immunization with whole blood from F1 hybrid rats. The inhibitory effect may be due to nonspecific active immunization. Significance of blood transfusion with special reference to clinical immunotherapy of cancer is discussed.