REACTIONS OF HUMAN SUBJECTS TO THE INJECTION OF PURIFIED TYPE SPECIFIC PNEUMOCOCCUS POLYSACCHARIDES 1

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Abstract
Type-specific polysaccharides prepared from pneumococci Types I, IV, V. VII, and XIV were all shown to be capable of stimulating the production of homologous type-specific antibodies in human subjects. Except for the Type XIV prep., each gave slight to moderate local reaction in some of the subjects to whom it was given either in a 1 mg. dose subcut. or in a 0.01 mg. amount intracut. Subsequent skin tests with each of the preps. gave a higher frequency of immediate and delayed reactions regardless of whether the previous inj. was of the same or of another type. Positive immediate cutaneous reactions to initial inj. were not regularly associated with the presence of homologous type-specific antibodies in the serum. While 1 mg. subcut. of the Type I and Type VII preps, produced a better homologous type-specific antibody response than 0.01 mg. of the same material given intracut. this was not equally true of the other preps, used.