Acceleration of enzyme‐catalyzed reactions in organic solvents by crown ethers
- 1 January 1991
- journal article
- research article
- Published by Wiley in Recueil des Travaux Chimiques des Pays-Bas
- Vol. 110 (5) , 222-225
- https://doi.org/10.1002/recl.19911100516
Abstract
Crown ethers can strongly enhance the transesterification of N‐acetyl‐1‐phenylalanine ethyl ester with 1‐propanol catalyzed by α‐chymotrypsin in various organic solvents. Of the different crown ethers tested, 18‐C‐6 gave the best results. It was found that a macrocyclic effect is responsible for the observed rate enhancement. It is proposed that the water‐ and cation‐complexing ability of crown ethers plays a key role in the observed rate enhancement.Keywords
This publication has 18 references indexed in Scilit:
- Enzymic peptide synthesis via segment condensation in the presence of water mimicsJournal of the American Chemical Society, 1989
- Enzymatic catalysis in anhydrous organic solventsTrends in Biochemical Sciences, 1989
- Partition coefficients of crown ethersRecueil des Travaux Chimiques des Pays-Bas, 1989
- The effect of crown ethers on enzyme-catalysed reactions in organic solventsJournal of the Chemical Society, Chemical Communications, 1989
- A lipid-coated lipase as a new catalyst for triglyceride synthesis in organic solventsJournal of the Chemical Society, Chemical Communications, 1988
- Application of polyethylene glycol-modified enzymes in biotechnological processes: organic solvent-soluble enzymesTrends in Biotechnology, 1986
- Macrocyclic receptor molecules for guanidinium cations. 2. Synthesis and x-ray structures of 2,6-pyrido crown ethers and their guanidinium complexesThe Journal of Organic Chemistry, 1986
- Complexation of tert-butylammonium perchlorate by crown ethers in polar solvents studied by proton NMR spectroscopyJournal of the American Chemical Society, 1985
- Ring-contracted Crown Ethers: 14-Crown-5, 17-Crown-6, and Their Sila-analogues. Drastic Decrease in Cation-binding AbilityBulletin of the Chemical Society of Japan, 1984
- Facile synthesis of monoaza crown ethersJournal of the Chemical Society, Chemical Communications, 1981