ANTI-TUMOR ACTIVITY OF PLATINUM(II) COMPLEXES OF 1,2-DIAMINOCYCLOHEXANE ISOMERS
- 1 January 1980
- journal article
- research article
- Vol. 71 (5) , 637-643
Abstract
Dichloro, dibromo, oxalato, malonato, dinitrato, sulfato and mono and bis-(D-glucuronato) platinum(II) complexes of 1,2-diaminocyclohexane (dach) isomers were prepared and tested on L1210 mouse leukemia cells employing the NCI protocol for evaluation of Pt analogs. A large number of long-term survivors were observed with certain analogs, though the therapeutic indices (optimal dose/minimum effective dose) were not large. Among the analogs tested, the oxalato, malonato, dinitrato and mono-(D-glucuronato) Pt(II) complexes of trans-1-1,2-diaminocyclohexane were particularly effective. The glucuronato Pt complexes appear to be promising candidates for clinical trial since they have the highest solubility in water.This publication has 3 references indexed in Scilit:
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- EXAMINATION OF ANTITUMOR ACTIVITIES OF PLATINUM COMPLEXES OF 1,2-DIAMINOCYCLOHEXANE ISOMERS AND THEIR RELATED COMPLEXES1976
- Studies on the antitumor activity of group VIII transition metal complexes. Part I. Platinum (II) complexesBioinorganic Chemistry, 1973