Metabolic Response to Electrical Stimulation in Separated Portions of Human Cerebral Tissues

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Abstract
Electrical stimulation of different areas of the human brain has hitherto been confined to experiments with the brainin situ, in living subjects. It has been carried out while the brain received its blood supply from normal sources. By chemical analysis of the arterial and venous blood and measurement of its rate of flow, information has been obtained on how metabolic changes in the brain vary with changes in its activity. However, these conditions can give information only about gross biochemical changes associated with stimulation; they are cumbersome, and would not indicate abnormal reactions in small areas. Also, they detect differences only in substances which are actively exchanged with the blood stream.