A distinct 2,5‐di‐(tert‐butyl)‐1,4‐benzohydroquinone‐sensitive calcium store in bovine adrenal chromaffin cells

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Abstract
The fluorescent Ca2+ indicator Fura 2 was used to monitor Ca2+ release induced by the Ins(1,4,5)P3‐mobilizing agonist angiotensin II (Ag II), caffeine and 2,5‐di‐(tert‐butyl)‐1,4‐benzohydroquinone (tuBHQ), in intact bovine adrenal chromaffin cells. Under low external Ca2+ conditions, tuBHQ, Ag II and caffeine elicited Ca2+ rises, indicating Ca2+ release from internal stores. Prior addition of Ag II had no noticeable effect on the extent of release of Ca2+ induced by tuBHQ. Stimulation of the cells with tuBHQ before either Ag II or caffeine, similarly had no effect on Ca2+ released by these two agonists. It was concluded, therefore, that there is a third intracellular Ca2+ store in bovine adrenal chromaffin cells, distinct and non‐overlapping, from those sensitive to caffeine or Ins(1,4,5)P3‐Mobilizing agonists.

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