Skeletal alterations in hypophysectomized rats: II. A histomorphometric study on tibial cortical bone

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Abstract
Background: Pituitary hormones play an important role in bone growth, modeling, and remodeling. The purpose of this study is to examine the effect of hypophysectomy (HX) on tibial cortical bone with histomorphometry. Methods: Forty‐Five female Sprague‐Dawiey rats, at 3 months of age, were hypophysectomized or served as intact controls. They were sacrificed at 0, 2, and 5 weeks after the surgery. Cortical bone histomorphometry was performed on double‐fluorescent‐labeled 30‐mcm‐thick sections of the tibial shaft. Results: The dry weight and density of tibial diaphysis and the cortical bone area of the tibial shaft in the HX rats were significantly lower (PPPConclusions: Hypophysectomy‐suppressed, radial growth‐dependent bone gain without a bone loss in the tibial shaft of the young rat. This is associated with decreased modeling‐dependent bone formation. A greater eroded surface on the endosteum did not affect the marrow size at 5 weeks after hypophysectomy.