Characterization of a High-Molecular-Weight Notch Complex in the Nucleus of Notchic-Transformed RKE Cells and in a Human T-Cell Leukemia Cell Line

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Abstract
In response to the Covid-19 pandemic epicenter in Bronx NY, our Neuroscience center required rapid and drastic changes when considering the delivery of neurologic care, health and safety of staff, and continued education and safety for house-staff. In healthcare, we rely on principles that can be in conflict during a disaster response such as this pandemic, with equal commitments to ensure the best care for those stricken with Covid-19, provide high quality care and advocacy for patients and families coping with neurologic disease, and advocate for the health and safety of healthcare teams, particularly house-staff and colleagues who are most vulnerable. In our attempt to balance these principles, over three weeks, we reformatted our inpatient neuroscience services by reducing from four wards to just one, still delivering care to over 600 hospitalized neuro-covid patients and over 1742 total neuroscience hospital bed days. This description from members of our leadership team provides an on-the-ground account of our effort to respond nimbly to a complex and evolving surge of Covid patients in a large urban hospital network. Our efforts were based on (1) strategies to mitigate exposure and transmission, (2) protection of the health and safety of staff, (3) alleviation of logistical delays and strains in the system, and (4) facilitating coordinated communication. Each center’s experience will add to knowledge of best practices and emerging research will help us with insights toward an evidence-based approach to neurologic care during and after the Covid-19 pandemic.