Effects of Dietary Aureomycin upon the Intestinal Microflora and the Intestinal Synthesis of Vitamin B12 in the Rat

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Abstract
The feeding of aureomycin stimulated the growth of weanling male albino rats maintained on purified rations limiting in methionine or vitamin B12, or both, but was without effect on the growth of rats fed a practical diet. Dietary aureomycin was found to cause a rapid, statistically significant change within the intestinal microflora of the rat, particularly among the coliform, enterococcus and lactobacillus groups of bacteria. A large portion of the flora, notably coliforms, developed resistance to aureomycin. These changes occurred in fecal droppings as well as in the cecum and ileum. Vitamin B12 was synthesized in the intestines of rats fed rations (with or without aureomycin) deficient in this factor. No conclusive effect of aureomycin on the concentration of vitamin B12 in the intestinal tract was demonstrated.

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