RESULTS OF LOCAL TRANS-URETHRAL HIGH-FREQUENCY HYPERTHERMIA IN BLADDER-CARCINOMA

  • 1 January 1982
    • journal article
    • research article
    • Vol. 21  (1) , 12-19
Abstract
On the basis of controversial results from the clinical use of hyperthermal irrigation of the bladder lumen published by various authors, a procedure was developed for transurethral local high frequency hyperthermia using phantom experiments and experimental bladder tumors. Encouraging results from experiments on animals led to clinical use of this technique with pretreated recurring [human] bladder tumors (n = 64) at various stages. Poorly differentiated tumors at higher stages responded especially well. Typical pathohistological findings induced by hyperthermia were extensive tumor necroses and as a late finding stromal hyalinoses. Permanent changes of tumor-free urothelium were not observed. During the observation period (maximum of 48 mo.), the 3-yr-survival rate was 92.5% (stage T1G2-3), 59.4% (T2G3) and 22.0% (T3G3).

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