Contrast medium-induced renal vasoconstriction and endogenous vasoconstrictor hormones

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Abstract
Hypertonic solutions such as contrast media (meglumine/sodium diatrizoate 76%; Renografin-76) induce vasoconstriction in the renal vascular bed via an unknown mechanism. A possible role of 2 vasoconstrictor hormones released by the kidney, angiotensin II (AII) and the prostaglandin [PG] thromboxane, was assessed in dogs. Specific inhibition of AII at the smooth muscle receptor level by saralasin (0.33-0.75 .mu.g/kg per min, intraarterially) did not attenuate the response. PG formation inhibition by indomethacin (4 mg/kg), i.v. did not prevent the decrease in renal perfusion. Evidently, neither AII nor the PG system mediates the contrast medium-induced renal vasoconstriction.