Clinical significance of serum hydroxyproline‐containing peptides with special reference to hyproprotein

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Abstract
Serum hydroxyproline-containing peptides were separated into 3 fractions (large protein, polypeptide and smaller peptides) by gel filtration on Sephadex G-200. The large protein was presumed to be the C1q subunit of the 1st component of complement by an immunological analysis. The polypeptide had an electrophoretic mobility corresponding to .beta.-globulin and its MW was estimated as 35,000-45,000 by gel filtration analysis. The polypeptide might well be defined as hyproprotein. The MW of smaller peptides was estimated as 1400-3000. As compared with the control value, hyproprotein levels were significantly increased in rheumatoid arthritis, systemic lupus erythematosus and chronic liver disease. C1q levels were slightly lowered in rheumatoid arthritis and systemic lupus erythematosus, and were slightly increased in chronic liver disease but were not significant. In all patient groups smaller peptide levels remained in the normal range. Serum hyproprotein levels apparently are raised in some fibroproliferative disorders, probably reflecting collagen metabolism.