Thiopental and Thyroid Metabolism.

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Abstract
Studies with S35 thiopental and I131 iodide indicated that the degree of inhibition of iodide metabolism in the thyroid produced by thiopental was inversely related to the concentration of the S35 in the thyroid. Studies with hypophysectomized rats indicated inhibition of I131 incorporation to be due to the reduction of I2 to I- by the thiocarbamate. S35 activity in the pituitary and adrenal showed no relation to the reduced iodine metabolism in the thyroid. The ratios of I131 di-iodotyrosine to I131 thyroxine to inorganic I131 of the thyroids were found to be the same in thiopental treated and non-treated animals indicating that the thiocarbamate did not directly interfere with the synthesis of thyroxine.