Representation of Heavy but Not Light Chain Ig Idiotypes on T Cell Receptors for Alloantigens

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Abstract
We have analyzed idiotypic determinants on B and T lymphocytes reactive against the same antigenic determinants by the use of different anti-idiotypic antibodies. Such antisera were produced in (Lewis × DA) F, rats against Lewis anti-DA alloantibodies (= B cell product) and Lewis T lymphocyte receptors with the same specificity. We found that B lymphocytes bear unique idiotypic determinants which are not present on the corresponding T lymphocytes. T cell unique (not shared by B lymphocytes) idiotypes were so far not detected. T cells share idiotypic determinants which are present on heavy but not light chains of the corresponding alloantibodies.