Central Role of Peroxisome Proliferator–Activated Receptors in the Actions of Peroxisome Proliferators
Top Cited Papers
- 1 April 2000
- journal article
- review article
- Published by Annual Reviews in Annual Review of Pharmacology and Toxicology
- Vol. 40 (1) , 491-518
- https://doi.org/10.1146/annurev.pharmtox.40.1.491
Abstract
Peroxisome proliferators (PPs) are a large class of structurally dissimilar chemicals that have diverse effects in rodents and humans. Most, if not all, of the diverse effects of PPs are mediated by three members of the nuclear receptor superfamily called peroxisome proliferator-activated receptors (PPARs). In this review, we define the molecular mechanisms of PPs, including PPAR binding specificity, alteration of gene expression through binding to DNA response elements, and cross talk with other signaling pathways. We discuss the roles of PPARs in growth promotion in rodent hepatocarcinogenesis and potential therapeutic effects, including suppression of cancer growth and inflammation.Keywords
This publication has 125 references indexed in Scilit:
- Identification of ARA70 as a Ligand-enhanced Coactivator for the Peroxisome Proliferator-activated Receptor γJournal of Biological Chemistry, 1999
- Identification of Nuclear Receptor Corepressor as a Peroxisome Proliferator-activated Receptor α Interacting ProteinPublished by Elsevier ,1999
- L-764406 Is a Partial Agonist of Human Peroxisome Proliferator-activated Receptor γPublished by Elsevier ,1999
- Synthesis of Retinoid X Receptor-Specific Ligands That Are Potent Inducers of Adipogenesis in 3T3-L1 CellsJournal of Medicinal Chemistry, 1999
- Receptor-interacting protein 140 interacts with and inhibits transactivation by, peroxisome proliferator-activated receptor α and liver-X-receptor αMolecular and Cellular Endocrinology, 1998
- Induction of PPARγ1 Expression in Human THP-1 Monocytic Leukemia Cells by 9-cis-Retinoic Acid Is Associated with Cellular Growth SuppressionBiochemical and Biophysical Research Communications, 1998
- Terminal Differentiation of Human Breast Cancer through PPARγMolecular Cell, 1998
- Elevated 8-hydroxydeoxyguanosine in hepatic DNA of rats following exposure to peroxisome proliferators: relationship to mitochondrial alterationsCarcinogenesis: Integrative Cancer Research, 1995
- Enhancement of peroxisomal enzymes, cytochrome P-452 and DNA synthesis in putative preneoplastic foci of rat liver treated with the peroxisome proliferator nafenopinCarcinogenesis: Integrative Cancer Research, 1993
- Peroxisome proliterators and cancer: mechanisms and implicationsTrends in Pharmacological Sciences, 1986