Metronidazole-resistant Trichomonas vaginalis.

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Abstract
A 36-yr-old woman with symptomatic metronidazole-resistant trichomonal vaginitis for 10 yr had 22 courses of treatment with metronidazole or tinidazole according to different schedules. The minimum trichomonicidal concentration of metronidazole for the strain of T. vaginalis isolated from the patient was 160 .mu.g/ml compared with 1.25-10 .mu.g/ml for other freshly isolated strains. The former strain showed a definitely decreased sensitivity to ornidazole and tinidazole (80 .mu.g/ml). The mechanisms behind the appearance of resistance in this clinical isolate are unknown.