Chromosomal localization of human genes governing the interferon-induced antiviral state.

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Abstract
Interferon sensitivity of different normal and aneusomic human cells and of different mouse-human hybrids cells was compared. G21 trisomic cells are more sensitive than diploid cells, but triploid cells are normal in their human interferon sensitivity. Among other aneusomic cell lines tested, E16 trisomic cells are significantly less sensitive. The G21 chromosome probably carries genetic information for structural proteins involved in the receptor system for interferon; there is a regulatory mechanism governing the antiviral state and the E16 chromosome is a possible candidate for carrying information for such a depressive regulatory mechanism. None of the chromosome abnormalities studied are involved with interferon synthesis.