Studies in detoxication. 61. The metabolism of alkylbenzenes. tert.-Butylbenzene
- 1 January 1955
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 59 (1) , 159-161
- https://doi.org/10.1042/bj0590159
Abstract
Tert.-butylbenzene is oxidized in rabbits mainly to 2:2-dimethyl-2-phenylethanol (up to 90% of the dose), which is excreted as a glucuronide, characterized as a triacetyl methyl ester. Traces of alpha-alpha-dimethylphenylacetic acid may also be formed. 2:2-Dimethyl-2-phenylethanol is not oxidized in rabbits to any appreciable extent, and 90-100% of doses of 150-300 mg/kg is excreted as 2:2-dimethyl-2-phenylethyl glucosiduronic acid, which is identical with the glucosiduronic acid excreted after feeding tert.-butylbenzene.Keywords
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