The mRNA cap-binding protein eIF4E in post-transcriptional gene expression
- 25 May 2004
- journal article
- review article
- Published by Springer Nature in Nature Structural & Molecular Biology
- Vol. 11 (6) , 503-511
- https://doi.org/10.1038/nsmb779
Abstract
Eukaryotic initiation factor 4E (eIF4E) has central roles in the control of several aspects of post-transcriptional gene expression and thereby affects developmental processes. It is also implicated in human diseases. This review explores the relationship between structural, biochemical and biophysical aspects of eIF4E and its function in vivo, including both long-established roles in translation and newly emerging ones in nuclear export and mRNA decay pathways.Keywords
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