Aging of Collagen in vitro

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Abstract
Swelling, solubility and chemical contraction-relaxation of tendon fibers taken from rat tails of different age, was studied in fresh state, and following a longer period storing at 20[degree]C. Collagen in vitro changes its structural stability and grows "old" more rapidly than in vivo. Swelling of the stored tendon fibers is progressively markedly decreased. Young, originally soluble fibers become insoluble. After a long period of storing the young fibers do not relax after chemical contraction.