HLA associations in insulin-dependent diabetes mellitus diagnosed during pregnancy
- 1 November 1987
- journal article
- research article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. 116 (3) , 387-389
- https://doi.org/10.1530/acta.0.1160387
Abstract
Sixty out of 63 patients with insulin-dependent diabetes mellitus (IDDM) diagnosed during pregnancy in the Diabetes Centre at the Department of Obstetrics and Gynaecology, Rigshospitalet, Copenhagen, were re-examined 2–16 years after diagnosis. Fourty-six patients were currently insulin-treated and the remaining 14 patients were all severely glucose intolerant. HLA-typing was carried out in 41 of these patients. The HLA phenotype distribution showed a highly significant difference from that of non-diabetics but was similar to that seen in IDDM not related to pregnancy. Thus, pregnancy may constitute a special trigger mechanism for IDDM, but the subsequent pathogenic mechanisms are probably the same as those involved in other cases of IDDM.This publication has 5 references indexed in Scilit:
- Increased incidence of true type I diabetes acquired during pregnancy.BMJ, 1987
- HLA associations in insulin‐dependent diabetes: search for heterogeneity in different groups of patients from a homogeneous populationTissue Antigens, 1986
- HLA haplotype study of 53 juvenile insulin‐dependent diabetic (I.D.D.) familiesTissue Antigens, 1982
- HLA-DR phenotype and HLA-B,DR haplotype frequencies in 704 unrelated DanesTissue Antigens, 1981
- HLA-D and -DR antigens in genetic analysis of insulin dependent diabetes mellitusDiabetologia, 1981