DECREASE IN GENERATION OF REACTIVE OXYGEN SPECIES BY NEUTROPHILS FROM PATIENTS WITH INFECTIOUS MONONUCLEOSIS - ROLE OF SUPPRESSOR LYMPHOCYTES-T

  • 1 January 1984
    • journal article
    • research article
    • Vol. 64  (5) , 994-999
Abstract
The generation of reactive O2 species (ROS: O2-, H2O2, OH., chemiluminescence) by neutrophils and monocytes from 6 patients with infectious mononucleosis, 10 patients with other viral diseases, and 10 normal controls was assessed. Neutrophils from infectious mononucleosis patients showed markedly decreased generation of all reactive O2 species, compared with the 2 control groups; this abnormality persisted for 4-8 wk after disease onset. Monocytes from these patients generated normal levels of ROS. Normal neutrophils incubated with T lymphocytes from infectious mononucleosis patients generated significantly less of each ROS than did those incubated with T cells from either control group. T cell-mediated suppression of ROS generation required both OKT4+ cells from infectious mononucleosis patients and OKT8+ cells from either patients or normals. The generation of reactive oxygen species in neutrophils is suppressed in patients with infectious mononucleosis, at least in part, by interacting subsets of T lymphocytes.

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