Diphenylhydantoin-Induced Cerebellar Degeneration
- 1 November 1972
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 27 (5) , 453-455
- https://doi.org/10.1001/archneur.1972.00490170085012
Abstract
Two patients received large amounts of diphenylhydantoin for 28 months or more. While receiving diphenylhydantoin, they acquired severe cerebellar deficits and a peripheral neuropathy that was irreversible. In each case, marked cerebellar atrophy was demonstrated by pneumoencephalography. The cerebellar atrophy and irreversible dysfunction in these two cases is attributed to long-term, high dosages of diphenylhydantoin.Keywords
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