Correlation between Antibacterial Power and Chemical Structure of Higher Alkyl Ammonium Ions

Open Access
Publisher Website
Google Scholar
Abstract
The germicidal activity, against Staphylococcus aureus and Eberthella typhi, of the following compounds was determined: halides of normal primary higher aliphatic (C10, C12, C14, C16, C18) amines; their tertiary dimethyl derivatives; quaternary methyl, ethyl, allyl, and benzyl derivatives of these tertiary amines; a few closely related ammonium halides. The effect of the chain length of the higher aliphatic radical and that of the nature of the lower alkyl substituent on the germicidal activity are interdependent. In many cases, the [image]-9-octa-decenyl derivatives exhibited a superior antibacterial efficacy, as compared with the corresponding [image]-octadecyl derivatives.

This publication has 8 references indexed in Scilit: