Novobiocin; an inhibitor of the repair of UV-induced but not X-ray-induced damage in mammalian cells
- 1 January 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 7 (5) , 1311-1320
- https://doi.org/10.1093/nar/7.5.1311
Abstract
In addition to inhibiting replicative DNA synthesis in HeLa cells, novobiocin has a severe effect on the cellular response to UV irradiation, reducing the number of breaks made in pre-existing DNA by the excision repair process. The inhibition of UV repair by novobiocin is reflected in enhanced UV-killing of these cells. Rejoining of DNA after X irradiation is not impaired by novobiocin. The recognition and removal of UV damage may require unwinding of the DNA by gyrase, which--in bacteria--is the target for novobiocin.Keywords
This publication has 16 references indexed in Scilit:
- Repair and survival after UV in quiescent and proliferatingMicrotus agrestis cells: Different rates of incision and different dependence on DNA precursor supplyJournal of Cellular Physiology, 1979
- Single-strand breaks in DNA during repair of UV-induced damage in normal human and xeroderma pigmentosum cells as determined by alkaline DNA unwinding and hydroxylapatite chromatographyMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1979
- DNA damage in synchronized HeLa cells irradiated with ultravioletBiophysical Journal, 1979
- The influence of inhibitors on dimer removal and repair of single-strand breaks in normal and bromodeoxyuridine substituted DNA of HeLa cellsBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1978
- Antagonists of DNA gyrase inhibit repair and recombination of UV-irradiated phage lambda.Proceedings of the National Academy of Sciences, 1978
- Proteins that Affect DNA ConformationAnnual Review of Biochemistry, 1978
- Reversal of the changes in DNA and chromosome structure which follow the inhibition of UV-induced repair in human cellsBiochemical and Biophysical Research Communications, 1978
- DNA damage in ultraviolet-irradiated HeLa and CHO-Kl cells examined by alkaline lysis and hydroxyapatite chromatographyBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1977
- The effect of cytosine arabinoside on the frequency of single-strand breaks in DNA of mammalian cells following irradiation or chemical treatmentBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1977
- Escherichia coli DNA synthesis in vitro: insensitivity of ATP-dependent DNA repair to inhibition by novobiocinNucleic Acids Research, 1977