What association analysis can and cannot tell us about the genetics of complex disease
- 15 December 1994
- journal article
- research article
- Published by Wiley in American Journal of Medical Genetics
- Vol. 54 (4) , 318-323
- https://doi.org/10.1002/ajmg.1320540408
Abstract
Human genetics researchers have been intrigued for many years by weak‐to‐moderate associations between markers and diseases. However, in most cases of association, the cause of this phenomenon is still unknown. Recently, interest has grown in pursuing association studies for complex psychiatric diseases, either instead of or in addition to linkage studies. However, it is one thing to detect association; the next important step is to determine why. Here we consider what a disease‐marker association in the weak‐to‐moderate range (relative risk <5) can tell us about disease etiology. Two distinct models (not the only possibilities) which could explain such an association are formulated. One is a linkage disequilibrium or major disease gene model, involving tight linkage with a “necessary” major gene. The other is a pure association model, involving a “susceptibility” gene that has only a minor effect on disease state. It will be shown that association analysis cannot distinguish between these two models, and hence cannot elucidate the biological mechanism behind the association. (This statement holds for traditional population‐based association tests, as well as for more recent family‐based association tests.) The importance of drawing the distinction between these two genetic models and the implications for understanding the genetics of complex human disease will also be discussed.Keywords
This publication has 33 references indexed in Scilit:
- Alcoholism and the D2 dopamine receptor genePublished by American Medical Association (AMA) ,1993
- Association versus linkage studies in psychosis genetics.Journal of Medical Genetics, 1993
- Associations of disease with genetic markers: Déjà vu all over againAmerican Journal of Medical Genetics, 1993
- Candidate genes in psychiatry: An epidemiological perspectiveAmerican Journal of Medical Genetics, 1993
- Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's diseaseNature, 1991
- Tyrosine hydroxylase polymorphisms associated with manic-depressive illnessThe Lancet, 1990
- Juvenile myoclonic epilepsy (JME) may be linked to the BF and HLA loci on human chromosome 6American Journal of Medical Genetics, 1988
- HLA-DR effects in a large German IDDM datasetGenetic Epidemiology, 1986
- Epistasis effect: an alternative to the hypothesis of linkage disequilibrium in HLA associated diseasesAnnals of Human Genetics, 1980
- Heterogeneity in diabetes mellitus--update, 1978. Evidence for further genetic heterogeneity within juvenile-onset insulin-dependent diabetes mellitusDiabetes, 1978