Genetic analysis of influenza A virus (H5N1) derived from domestic cat and dog in Thailand
- 18 June 2007
- journal article
- Published by Springer Nature in Archiv für die gesamte Virusforschung
- Vol. 152 (10) , 1925-1933
- https://doi.org/10.1007/s00705-007-1010-5
Abstract
Complete genome sequences of H5N1 viruses derived from a domestic cat “A/Cat/Thailand/KU-02/04” and dog “A/Dog/Thailand/KU-08/04” were comprehensively analyzed and compared with H5N1 isolates obtained during the 2004 and 2005 outbreaks. Phylogenetic analysis of both cat and dog viruses revealed that they are closely related to the H5N1 viruses recovered from avian influenza outbreaks of the same period. Genetic analysis of 8 viral gene segments showed some evidence of virulence in mammalian species. In summary, the H5N1 viruses that infected a domestic cat and dog are highly pathogenic avian influenza viruses that are virulent in mammalian species, potentially indicating transmission of H5N1 viruses from domestic animals to humans.Keywords
This publication has 20 references indexed in Scilit:
- Fatal Avian Influenza A H5N1 in a DogEmerging Infectious Diseases, 2006
- Distribution of Amantadine‐Resistant H5N1 Avian Influenza Variants in AsiaThe Journal of Infectious Diseases, 2006
- Avian Influenza H5N1 in Naturally Infected Domestic CatEmerging Infectious Diseases, 2006
- Dogs can play useful role as sentinel hosts for diseaseNature, 2006
- Clues to the Virulence of H5N1 Viruses in HumansScience, 2006
- Establishment of multiple sublineages of H5N1 influenza virus in Asia: Implications for pandemic controlProceedings of the National Academy of Sciences, 2006
- Genetic characterization of H5N1 influenza A viruses isolated from zoo tigers in ThailandVirology, 2006
- Isolation of drug-resistant H5N1 virusNature, 2005
- Avian Influenza H5N1 in Tigers and LeopardsEmerging Infectious Diseases, 2004
- Molecular Basis for High Virulence of Hong Kong H5N1 Influenza A VirusesScience, 2001