Covalent association of protein with replicative form DNA of parvovirus H-1.
- 1 November 1979
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 76 (11) , 5539-5543
- https://doi.org/10.1073/pnas.76.11.5539
Abstract
The double-stranded replicative form (RF) DNA of the autonomous parvovirus H-1 can be isolated from infected [human embryonic kidney] cells in a covalent complex with protein. The protein is present on most or all of the RF DNA, including actively replicating molecules, and is associated with the 5''-terminal endonuclease Hae III fragments of both the viral and complementary strands of RF. The size of the protein is estimated to be 60,000-70,000 daltons from its effect on buoyant density of DNA. DNA with covalently bound protein was not found in H-1 virions.Keywords
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