THE ADRENAL CORTEX AND RENAL SODIUM AND POTASSIUM EXCRETION IN THE NEWBORN RAT

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Abstract
SUMMARY: 1. The effects of an aldosterone blocking agent (SC-11927) and of corticotrophin, aldosterone and cortisol on renal function were tested on infant rats aged 1 to 17 days. 2. SC-11927 had no effect on the Na/K ratio in the urine of rats until they were 12 days old. 3. d-Aldosterone depressed the Na/K ratio on the 1st day after birth, potassium concentration increased but a decrease in sodium concentration was not seen until the 6th day. 4. Cortisol elevated the Na/K ratio on the 1st day after birth, both sodium and potassium concentration increased. At 6 days potassium concentration alone was increased. 5. Corticotrophin did not affect the composition of the urine until the animals were 12 days old when the potassium concentration increased.