The Major Histocompatibility Complex of Rhesus Monkeys VI. Serology and Genetics of la‐Like Antigens*

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Abstract
The serology and genetics of 11 new cell surface alloantigens of rhesus monkeys are described. They are controlled by the major histocompatibility complex, but are distinct from the conventional serologically defined (SD) antigens of RhL-A. The new specificities are termed Ia-like because of serological, immunocytological and other characteristics reminiscent of Ia-antigens of the mouse. Population and family analyses led to the postulation of 2 segregant series controlling 8 of the 11 Ia-like specificities of the monkey. Strong linkage disequilibria with SD2 antigens and genetic mapping on the basis of segregation studies in recombinant offspring in the monkey families, places at least 1 of the 2 loci in the vicinity of the SD2 locus of RhL-A, not in the region of the major MLC [mixed lymphocyte culture] or LD1 locus. The new B[bone marrow-derived]-cell alloantigens of rhesus monkeys are apparently not similar to or associated with the stimulator antigens of LD1. The biological function(s) of the Ia-like antigens of primates are as yet unknown.