Second‐trimester unconjugated oestriol levels in maternal serum from chromosomally abnormal pregnancies using an optimized assay
- 1 April 1993
- journal article
- research article
- Published by Wiley in Prenatal Diagnosis
- Vol. 13 (4) , 271-280
- https://doi.org/10.1002/pd.1970130406
Abstract
Second-trimester unconjugated oestriol (UE3) levels were measured retrospectively in maternal serum from 78 chromosomally abnormal pregnancies and 390 matched controls using a radioimmunoassay kit (Amersham AMERLEX-M) optimized for use in the second trimester. Reduced levels of UE3 were found in a group of 49 Down's syndrome pregnancies with a median UE3 level of 0·79 multiples of the median (MOM) of the controls. Four trisomy 18 pregnancies had UE3 levels less than 0·7 MOM. There was a highly significant level of correlation between alpha-fetoprotein (AFP) and UE3 levels in the controls (r = 0·25, P r = 0·44, p 0·01), and the other chromosome abnormalities (r = 0·61, p0·01). When used as an additional marker to AFP and human chorionic gonadotrophin in screening for Down's syndrome, UE3 does not appear to add to the sensitivity of such screening.Keywords
This publication has 20 references indexed in Scilit:
- Screening for fetal Down's syndrome with maternal serum markers—an experience in italyPrenatal Diagnosis, 1991
- Prenatal screening for chromosome abnormalities using maternal serum chorionic gonadotrophin, alpha‐fetoprotein, and agePrenatal Diagnosis, 1991
- Maternal serum markers in screening for Down syndromeClinical Genetics, 1990
- SECOND TRIMESTER SCREENING FOR TRISOMY 21The Lancet, 1989
- Frequency of heterozygous complete hydatidiform moles, estimated by locus-specific minisatellite and Y chromosome-specific probesHuman Genetics, 1989
- Maternal serum screening for Down's syndrome in early pregnancy.BMJ, 1988
- Maternal serum unconjugated oestriol as an antenatal screening test for Down's syndromeBJOG: An International Journal of Obstetrics and Gynaecology, 1988
- Low second trimester maternal serum unconjugated oestriol in pregnancies with Down's syndromeBJOG: An International Journal of Obstetrics and Gynaecology, 1988
- Abnormal maternal serum chorionic gonadotropin levels in pregnancies with fetal chromosome abnormalitiesPrenatal Diagnosis, 1987
- Estimating a woman's risk of having a pregnancy associated with Down's syndrome using her age and serum alpha‐fetoprotein levelBJOG: An International Journal of Obstetrics and Gynaecology, 1987