Effects of Glucose Analogues (2-Deoxy-d-glucose, 2-Deoxy-d-galactose) on Experimental Tumors

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Abstract
The effects of the glucose antagonists, 2-deoxy-d-glucose and 2-deoxy-d-galactose, have been studied on solid, ascitic, and systemic transplantable tumors in mice. Inhibition of tumor growth was noted in each instance and a modest prolongation of survival time attained with most tumors. These effects were more extensive than those achieved with rigorous caloric restriction alone. The results are considered consistent with the hypothesis that interference with glycolysis at the hexokinase reaction may be inhibitory to tumor growth.