INVITRO AND INVIVO STABILITY OF THE ENTRAPMENT OF METHOTREXATE IN NEGATIVELY CHARGED LIPOSOMES AFTER STERILE FILTRATION

  • 1 January 1979
    • journal article
    • research article
    • Vol. 34  (1-2) , 114-119
Abstract
The preparation of sterile artificial liposomes (phosphatidylcholine:cholesterol:dicethylphosphate = 5:5:1) by Millipore filtration is described. Conditions for storing liposome entrapped methotrexate [an antineoplastic drug] were found which allow storage of the drug in the entrapped form for at least 4 mo. I.v. injected [mouse] liposome entrapped methotrexate is retained for at least 15 h in the particulate form. During this time no free methotrexate was detectable in the blood.

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