ACTION SPECTRA FOR ULTRAVIOLET LIGHT-INDUCED TRANSFORMATION OF HUMAN-CELLS TO ANCHORAGE-INDEPENDENT GROWTH
- 1 January 1981
- journal article
- research article
- Vol. 41 (6) , 2211-2214
Abstract
Action spectra for transformation of human embryonic skin and muscle fibroblasts to anchorage-independent growth were determined. Tests under experimental conditions indicate that reciprocity holds for photon rate and exposure time and that all the dose-effect curves in the wavelength range of 248-297 nm are similar. These data can be used to construct action spectra with a maximum at .apprx. 265 nm, which do not implicate moieties other than nucleic acids as absorbers in the transformation process. [This data can be used to quantitate the oncogenic effects of sunlight on human cells.].This publication has 4 references indexed in Scilit:
- ACTION SPECTRA FOR KILLING NON‐DIVIDING NORMAL HUMAN AND XERODERMA PIGMENTOSUM CELLSPhotochemistry and Photobiology, 1980
- ULTRAVIOLET LIGHT-INDUCED TRANSFORMATION OF HUMAN-CELLS TO ANCHORAGE-INDEPENDENT GROWTH1980
- AN ACTION SPECTRUM FOR CELL KILLING AND PYRIMIDINE DIMER FORMATION IN CHINESE HAMSTER V‐79 CELLSPhotochemistry and Photobiology, 1979
- Culture conditions affect photoreactivating enzyme levels in human fibroblastsBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1976