Design and synthesis of novel 2,7-dialkyl substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamides as in vitro potent peptidomimetic inhibitors of human renin
- 1 November 1997
- journal article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 7 (21) , 2735-2740
- https://doi.org/10.1016/s0960-894x(97)10067-1
Abstract
No abstract availableKeywords
This publication has 20 references indexed in Scilit:
- Bioactive hydroxyethylene dipeptide isosteres with hydrophobic (P3-P1)-moieties. A novel strategy towards small non-peptide renin inhibitorsBioorganic & Medicinal Chemistry Letters, 1996
- Design and Synthesis of Renin Inhibitors: Incorporation of Transition-State Isostere Side Chains That Span from the S1 to the S3 Binding Pockets and Examination of P3-Modified Renin InhibitorsJournal of Medicinal Chemistry, 1995
- Pharmacology of renin inhibitors and their application to the treatment of hypertensionPharmacology & Therapeutics, 1994
- Design and synthesis of a prototypical non-peptidic inhibitor model for the enzme reninBioorganic & Medicinal Chemistry Letters, 1994
- Peptidomimetic inhibitors of renin incorporating topographically modified isosteres spanning the P1(→ P3)-P1' sitesBioorganic & Medicinal Chemistry Letters, 1993
- Highly potent, orally active diester macrocyclic human renin inhibitorsJournal of Medicinal Chemistry, 1992
- The crystal structures of recombinant glycosylated human renin alone and in complex with a transition state analog inhibitorJournal of Structural Biology, 1991
- Non-peptide ligands for peptide receptorsTrends in Pharmacological Sciences, 1989
- Synthesis and biological activity of some transition-state inhibitors of human reninJournal of Medicinal Chemistry, 1988
- Enantioselektive Synthese von (R)‐Aminosäuren unter Verwendung von L‐Valin als chiralem HilfsstoffAngewandte Chemie, 1981