Acetaminophen and Aspirin Challenges in Subgroups of Asthmatics

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Abstract
To determine whether the different modes of action of aspirin and acetaminophen are associated with different incidences of bronchoconstriction, and whether there is cross-reactivity in terms of intolerance, selected asthmatics were challenged with both analgesics. Clinical profiles were observed to characterize more precisely the aspirin-intolerant asthmatic. Inhalational challenges with PGF2 alpha were then performed on nine selected subjects. It was determined that a positive history of aspirin intolerance is a reliable indicator of potential for anaphylactoid reactions but is not associated with any detectable risk of acetaminophen intolerance. Inhalational PGF2 alpha tends to involve the larger airways; oral aspirin affects both large and small airways.

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