Genetic polymorphism of the vitamin D binding protein (Gc) in the musk shrew (Suncus murinus)
- 24 April 2009
- journal article
- research article
- Published by Wiley in Animal Blood Groups and Biochemical Genetics
- Vol. 15 (1) , 55-61
- https://doi.org/10.1111/j.1365-2052.1984.tb01097.x
Abstract
In the musk shrew (S. murinus), the electrophoretic bands in the post-albumin region were identified as vitamin D binding protein (Gc) by the [3H]vitamin D3 binding method. Three Gc phenotypes were distinguished from each other: a single faster band (Gc-A), a single slower band (Gc-B) and the double bands (Gc-AB). Mating experiments indicated that the Gc-A and Gc-B are controlled by 2 codominant alleles, Gca and Gcb at an autosomal locus (Gc), respectively. In the Gc-AB phenotypes, the Gc-B band was constantly more intense than the Gc-A band in the protein staining. The same tendency was also observed between the homozygous Gc-A and Gc-bands, and further, radioactivity of the Gc-B bound with [3H] vitamin D3 was about 2-fold higher than that of the Gc-A. The Gcb yields its protein product 2-fold more than the Gca. No cross-reaction between the shrew proteins and a rabbit anti-human Gc protein was observed.Keywords
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