Formation of bis(phosphatidyl)inositol and phosphatidic acid by phospholipase D action on phosphatidylinositol

Abstract
Phosphatidylinositol is readily attacked by phospholipase D. Although some phosphatidic acid is produced by hydrolysis, the main products are bis(phosphatidyl)inositols most likely formed by a transphosphatidylation reaction between two substrate molecules.