CuI/l-Proline-Catalyzed Coupling Reactions of Aryl Halides with Activated Methylene Compounds
- 23 September 2005
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 7 (21) , 4693-4695
- https://doi.org/10.1021/ol0518838
Abstract
The arylation of ethyl acetoacetate, ethyl benzoyl acetate, and diethyl malonate under the catalysis of CuI/l-proline in DMSO proceeds smoothly at 40−50 °C in the presence of Cs2CO3 to provide the 2-aryl-1,3-dicarbonyl compounds in good yields. Both aryl iodides and aryl bromides are compatible with these reaction conditions.Keywords
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